FULL TEXT ARTICLE DOI: 10.1016/j.clim.2021.108696 Authors: Ibnu A. Ariyanto, Silvia Lee, Riwanti Estiasari, Jeanne Edmands, Budiman Bela, Amin Soebandrio, Patricia Price Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before...Read More
FULL TEXT ARTICLE DOI:10.1177/11795735211057314 Authors: Fu Liong Hiew, Win Min Thit, Mathew Alexander, Umapathi Thirugnanam, Sasitorn Siritho, Kevin Tan, Seinn Mya Mya Aye, Ohnmar Ohnmar, Riwanti Estiasari, Norazieda Yassin, Paul Matthew Pasco, Say Saysavath Keosodsay, Hoang Tien Trong Nghia, MD Badrul Islam, Sing Keat Wong, Shirley Lee, Anupam Chhabra, and Shanthi Viswanathan Therapeutic plasma exchange (TPE)...Read More
FULL TEXT ARTICLE DOI: 10.2147/HIV.S333469 Authors: Teguh Harjono Karjadi, Suzy Maria, Evy Yunihastuti, Alvina Widhani, Nia Kurniati, Darma Imran Purpose: This study aimed to analyze the knowledge, attitude, and behavior of people living with HIV (PLWH) during the COVID-19 pandemic and the pandemic’s impact on their socioeconomic conditions, antiretroviral adherence, and worries. Materials and Methods:...Read More
FULL TEXT ARTICLE DOI:10.1111/myc.13304 Authors: Retno Wahyuningsih, Robiatul Adawiyah, Ridhawati Sjam, Joedo Prihartono, Endah Ayu Tri Wulandari, Anna Rozaliyani, Robertus Ronny, Darma Imran, Mulyati Tugiran, Forman E. Siagian, David W. Denning Background: Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden help policymakers and clinicians. Objectives: We have...Read More
FULL TEXT ARTICLE DOI:10.1155/2021/5573839 Authors: Riwanti Estiasari, Adisresti Diwyacitta, Muhammad Sidik, Ni Nengah Rida Ariarini, Freddy Sitorus, Saraf Shafa Marwadhani, Kartika Maharani, Darma Imran, Reza Aditya Arpandy, David Pangeran, Manfaluthy Hakim Background: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve...Read More
FULL TEXT ARTICLE DOI:10.1016/j.clineuro.2021.106989 Authors: Sophie Yolanda, Kartika Maharani, Darma Imran, Riwanti Estiasari Tuberculoma of medulla oblongata is a rare manifestation of central nervous system tuberculosis (CNS TB), which may manifest as intractable singultus as the initial symptom. It is almost impossible to obtain definite diagnosis through biopsy consider its location. Immediate thorough diagnostic workup is...Read More
FULL TEXT ARTICLE DOI:10.1016/j.tube.2021.102085 Authors: Reinout van Crevel There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and...Read More
PROTOCOL Type of study: Observative cohort study Study design: A 2-year follow up cohort study involving adult with probable and definite TB meningitis enrolled in Jakarta and Bandung to assess systemic and local inflammatory responses, pharmacokinetic profile of first line anti-tuberculosis therapy and steroid, outcomes, and paradoxical reaction by conducting cerebrospinal fluid, whole blood, and skin...Read More
PROTOCOL Type of study: Phase III interventional clinical trial Study design: This was a multicenter, double-blind, randomized, placebo-controlled Phase III clinical trial conducted across Indonesia, South Africa, and Uganda between June 2019 and May 2023. Adults with tuberculous meningitis, with or without HIV coinfection, were randomly assigned to receive either high-dose rifampin (35 mg/kg/day) or standard-dose...Read More
