The Pathobiology Research Group is one of the academic and scientific platforms for faculty members in the Department of Anatomical Pathology at FKUI. The group’s research focuses on the field of pathobiology, particularly the study of cancer pathobiology. The research direction is centered on understanding the pathomechanisms of malignancy through the exploration of various cellular signaling pathways involved in transformation, proliferation, angiogenesis, and cancer cell metastasis. Numerous studies have been conducted by members of the Pathobiology Research Group to explore the relationship between molecular pathways and the potential use of synthetic drugs or unique Indonesian natural substances that can be used as preventive agents, alternative therapies, and adjuvants. These studies have resulted in many publications and patents.
In addition, cancer research is also conducted to observe the interaction between cancer cells and their microenvironment. Studies on the microenvironment carried out so far include the dynamics of the relationship between cancer cells and stromal cells, fibroblasts, as well as Tumor-Infiltrating Lymphocytes (TILs), which collectively form the tumor ecosystem. By understanding the pathomechanisms of cancer and the role of the tumor microenvironment in supporting or inhibiting cancer progression, the research conducted by the Pathobiology research group is expected to open opportunities for more effective and innovative diagnostic and therapeutic strategies.
In addition to conducting research activities, the Pathobiology research group also plays an active role in education and human resource development. This research group serves as a research-based learning platform for undergraduate, professional, and postgraduate students who want to deepen their knowledge in pathobiology and molecular biology. Through direct involvement in research activities, students are expected to gain practical experience, laboratory skills, and a profound understanding of disease mechanisms, particularly cancer.
This research group also supports curriculum development and the preparation of teaching materials integrated with the latest research findings, enabling the provision of education that is relevant, up-to-date, and applicable. With a multidisciplinary approach, the Pathobiology Research Group is committed not only to producing scientific discoveries that contribute to the advancement of basic science and cancer therapy but also to cultivating a generation of scientists, educators, and healthcare practitioners who are excellent, innovative, and globally competitive.
To expand the scope and enhance the impact of research outcomes, the Pathobiology research group will establish collaborations and cross-disciplinary partnerships both nationally and internationally to strengthen the development of knowledge in the field of pathobiology. Through these synergies, it is hoped that the foundation of a Pathobiology Association will be established, serving as a platform for exchanging ideas, research results, and the latest innovations. Furthermore, the group is also committed to the continuous dissemination of knowledge, so that research findings not only contribute to academic development but also have a tangible impact on the advancement of health sciences and the wider community.